Ángel Moisés Guzmán is a starting pitcher in major league baseball who plays for the Chicago Cubs. Listed at 6-3 , 195 pounds , Guzmán bats and throws right-handed. He is the brother of Daniel Guzmán. He made his major-league debut on April 26, 2006.

Guzmán began his professional career at age 18. That year, he went 1-1 with a 1.93 ERA for La Pradera in the Venezuelan Summer League. In 2001, he led a strong staff for the Boise Hawks, going 9-1 with a 2.23 ERA, 19 walks and 63 strikeouts in 77 innings pitched. He was second in the Northwest League in ERA, trailing Jesse Foppert, and he led the league in wins. He made the league All-Star team as the righty starter; the lefty was Dontrelle Willis, a teammate. He was rated the #4 prospect in the league according to Baseball America, two spots ahead of Willis.